Mendelsohn et al.’s study is important because it demonstrates that hypnotic suggestions influence brain activity, not just behavior and experience. Hypnotic effects are real! This fact has been demonstrated clearly in earlier work, for instance, by psychologist David Oakley (University College London) and colleagues, who compared brain activation of genuinely hypnotized people given suggestions for leg paralysis with brain activation of people simply asked to fake hypnosis and paralysis.
Research into hypnosis in military applications is further verified by the Project MKULTRA experiments, also conducted by the CIA.[149] According to Congressional testimony,[150] the CIA experimented with utilizing LSD and hypnosis for mind control. Many of these programs were done domestically and on participants who were not informed of the study's purposes or that they would be given drugs.[150]
Hypnosis (also known as "hypnotherapy") is often touted as a natural treatment for chronic sleep disorders, a problem estimated to affect millions of Americans each year. Although hypnosis has yet to be extensively studied in the treatment of insomnia and other sleep-related conditions, the existing research hints that hypnosis may be of some use in achieving sounder sleep.
Despite briefly toying with the name "rational Mesmerism", Braid ultimately chose to emphasise the unique aspects of his approach, carrying out informal experiments throughout his career in order to refute practices that invoked supernatural forces and demonstrating instead the role of ordinary physiological and psychological processes such as suggestion and focused attention in producing the observed effects.
Hypnosis -- or hypnotherapy -- uses guided relaxation, intense concentration, and focused attention to achieve a heightened state of awareness that is sometimes called a trance. The person's attention is so focused while in this state that anything going on around the person is temporarily blocked out or ignored. In this naturally occurring state, a person may focus his or her attention -- with the help of a trained therapist -- on specific thoughts or tasks.
Hypnosis typically involves an introduction to the procedure during which the subject is told that suggestions for imaginative experiences will be presented. The hypnotic induction is an extended initial suggestion for using one's imagination, and may contain further elaborations of the introduction. A hypnotic procedure is used to encourage and evaluate responses to suggestions. When using hypnosis, one person (the subject) is guided by another (the hypnotist) to respond to suggestions for changes in subjective experience, alterations in perception,[24][25] sensation,[26] emotion, thought or behavior. Persons can also learn self-hypnosis, which is the act of administering hypnotic procedures on one's own. If the subject responds to hypnotic suggestions, it is generally inferred that hypnosis has been induced. Many believe that hypnotic responses and experiences are characteristic of a hypnotic state. While some think that it is not necessary to use the word "hypnosis" as part of the hypnotic induction, others view it as essential.[27]
Abnormal results can occur in instances where amateurs, who know the fundamentals of hypnosis, entice friends to become their experimental subjects. Their lack of full understanding can lead to immediate consequences, which can linger for some time after the event. If, for example, the amateur plants the suggestion that the subject is being bitten by mosquitoes, the subject would naturally scratch where the bites were perceived. When awakened from the trance, if the amateur forgets to remove the suggestion, the subject will continue the behavior. Left unchecked, the behavior could land the subject in a physician's office in an attempt to stop the itching and scratching cycle. If the physician is astute enough to question the genesis of the behavior and hypnosis is used to remove the suggestion, the subject may experience long-term negative emotional distress and anger upon understanding exactly what happened. The lack of full understanding, complete training, and supervised experience on the part of the amateur places the subject at risk.
Émile Coué (1857–1926) assisted Ambroise-Auguste Liébeault for around two years at Nancy. After practising for several months employing the "hypnosis" of Liébeault and Bernheim's Nancy School, he abandoned their approach altogether. Later, Coué developed a new approach (c.1901) based on Braid-style "hypnotism", direct hypnotic suggestion, and ego-strengthening which eventually became known as La méthode Coué.[63] According to Charles Baudouin, Coué founded what became known as the New Nancy School, a loose collaboration of practitioners who taught and promoted his views.[64][65] Coué's method did not emphasise "sleep" or deep relaxation, but instead focused upon autosuggestion involving a specific series of suggestion tests. Although Coué argued that he was no longer using hypnosis, followers such as Charles Baudouin viewed his approach as a form of light self-hypnosis. Coué's method became a renowned self-help and psychotherapy technique, which contrasted with psychoanalysis and prefigured self-hypnosis and cognitive therapy.
But for the comparison between PHA and functional amnesia to be most meaningful, we need to know that they share underlying processes. One way to test this is to identify the brain activity patterns associated with PHA. In a groundbreaking study published in Neuron, neuroscientist Avi Mendelsohn and colleagues at the Weizmann Institute in Israel did just that using functional magnetic resonance imaging (fMRI). They carefully selected 25 people to participate in their experiment. Although all were susceptible to hypnosis, earlier testing had shown that half could respond to a PHA suggestion (labelled “the PHA group”) and half could not (the “non-PHA group”). In the Study session of their experiment, participants watched a 45-minute movie. One week later, in the Test session, participants returned to the laboratory and were hypnotized while they lay within the fMRI scanner. During hypnosis, people in both the PHA and non-PHA groups received a suggestion to forget the movie until they heard a specific cancellation cue.
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Many of us know exactly what we should be doing to address the situations we're uncomfortable with. When we want to lose weight we know we shouldn't eat emotionally, and that we should finally get around to joining that Zumba class or hiking group. We understand that logically, it's extremely unlikely that we'll be involved in a plane crash, so we should just book that long-awaited holiday. And when we're ready to quit smoking we know that we simply shouldn't light up that cigarette!

Austrian physician, Franz Mesmer (1734–1815), is credited with being the first person to scientifically investigate the idea of hypnotherapy, in 1779, to treat a variety of health conditions. Mesmer studied medicine at the University of Vienna and received his medical degree in 1766. Mesmer is believed to have been the first doctor to understand the relationship of psychological trauma to illness. He induced a trance-like state, which became known as mesmerism, in his patients to successfully treat nervous disorders. These techniques became the foundation for modern-day hypnotherapy.
Speech, on account of the whole preceding life of the adult, is connected up with all the internal and external stimuli which can reach the cortex, signaling all of them and replacing all of them, and therefore it can call forth all those reactions of the organism which are normally determined by the actual stimuli themselves. We can, therefore, regard "suggestion" as the most simple form of a typical reflex in man.[165]
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David Lesser[21] (1928 - 2001) was the originator of what we today understand by the term Curative Hypnotherapy.[22] It was he who first saw the possibility of finding the causes of people’s symptoms by using a combination of hypnosis, IMR and a method of specific questioning that he began to explore. Rather than try to override the subconscious information as Janet had done, he realised the necessity- and developed the process- to correct the wrong information. Lesser’s understanding of the logicality and simplicity of the subconscious led to the creation of the methodical treatment used today and it is his innovative work and understanding that underpins the therapy and is why the term ‘Lesserian[23]’ was coined and trademarked. As the understanding of the workings of the subconscious continues to evolve, the application of the therapy continues to change. The three most influential changes have been in Specific Questioning (1992) to gain more accurate subconscious information; a subconscious cause/effect mapping system (SRBC)(1996) to streamline the process of curative hypnotherapy treatment; and the ‘LBR Criteria’ (2003) to be able to differentiate more easily between causal and trigger events and helping to target more accurately the erroneous data which requires reinterpretation.